tio is a simple serial device tool which features a straightforward command-line and configuration file interface to easily connect to serial TTY devices for basic I/O operations. A simpler serial device tool for talking with serial TTY devices with less focus on classic terminal/modem features and more focus on the needs of embedded developers and hackers. tio was originally created to replace screen for connecting to serial devices when used in combination with tmux.

If it's a serial TTY device, it can talk to it. Sensible defaults (115200 8n1). Supports non-standard speeds, RS-485, multiple parity options.

Builds with Meson, for some reason. In the AUR.